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Staff Research Associate I

ResponsibilitiesUnder supervision of the Principal Investigator (Dr. Brent Fogel), the Research Associate I will perform computational and bioinformatic experiments to support research projects investigating the genetic underpinnings of neurological disorders.
Job duties primarily (90% or more) involve the analysis of next-generation genomic sequencing data to identify mutations and other forms of variation; utilizing and developing bioinformatic methodologies as well as using online and commercial resources to analyze genetic sequence variations and perform additional genomic assessments; data analysis and interpretation; maintaining clear documentation of experimental procedures and results; assisting with the generation of figures and text for grant applications and other publications; providing technical assistance to others in the lab; and assisting with training of lab assistants and students. Less frequent duties (10% or less) may include molecular and cellular biology techniques such as generating DNA plasmids; cell culture studies; performing PCR and gel electrophoresis; conducting real-time PCR experiments; isolating protein extracts and running Western blots; primary neuronal and cell line tissue culture; and/or preparing buffers, solutions, and chemicals for lab experiments.

QualificationsB.S. degree or equivalent in Bioinformatics, Computer Science, Computational Biology, Molecular Biology, Microbiology, Cell Biology, Biochemistry or related field. M.S. or Ph.D. in Bioinformatics or related degree strongly preferred.
General working knowledge of neuroscience, human genetics, molecular genetics, molecular biology, and/or cell biology theories and principles.
Good communication skills and ability to work well with multiple individuals.
Ability to maintain an organized working area.
Ability to work on several projects simultaneously and to switch focus as needed.
Excellent attention to detail, for accurate data entry and analysis.
Good organization and time management skills. Always punctual.
Ability to learn new laboratory techniques and new equipment, as needed.
Experience with bioinformatics sequencing methods (e.g., NGS and/or RNASeq) online tools, resources, and/or related commercial products.
Willingness to work occasional overtime in order to meet deadlines.
Working knowledge and ability to use computers (PC, MAC, and UNIX or related operating systems), software, and related hardware.
Familiarity with next-generation sequencing methods and analysis.
Working knowledge of bioinformatics, systems biology, and biostatistics.
Familiarity using online bioinformatic resources (e.g., 1000 Genomes Project, Exome Variant Server, dbSNP, UCSC Genome Browser, etc.) and/or related commercial products.
Experience in computer programming, particularly R and/or Perl.
Ability to keep accurate and organized records of experiments, procedures, and data.
Knowledge of basic molecular biology/cell biology/genetic techniques.
Knowledge of standard laboratory equipment and supplies.
Knowledge of chemistry to prepare solutions for lab experiments.
Knowledge of laboratory safety procedures for handling chemical, biohazard, and medical waste.
1+ years research and/or work experience in a bioinformatics-related position in genetics, neurology, molecular biology, or related field.
General working knowledge of neuroscience, human genetics, molecular genetics, molecular biology, and/or cell biology theories and principles.



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